For example, commonly used drugs for the control of hypertension (telmisartan and valsartan), hyperglycemia (glimepiride), and hyperuricemia (febuxostat, benzbromarone, etc.)displayed potent inhibition of OAT3-mediated uptake of enalaprilat, suggesting an interaction potential due to OAT3 inhibition. Here, SLC22A8 is linked to hypertensive disorder.