We noted the debate by Remédio and associates who proposed that dependently on species, the prepatterning of AChR clusters is influenced by an additional presence of Kringle domain in the MuSK extracellular region (Remédio et al., 2016; Burden et al., 2018); this is likely to augue against the participation of MuSK CRD in signaling variety in MuSK antibody-positive MG patients. The gene discussed is MUSK; the disease is myasthenia gravis.