The active immunization of mice with Lrp4 was proved to induce myasthenia gravis; the pathogenicity of Lrp4 antibodies was confirmed by the study in animal models that showed both pre- and post-synaptic impairments and active complements (Mori et al., 2012, 2017; Shen et al., 2013; Ulusoy et al., 2017). Here, LRP4 is linked to myasthenia gravis.