TARDBP and amyotrophic lateral sclerosis: Unlike TDP-43 pathology that can be detected in almost all ALS cases (Mackenzie et al., 2007), cytoplasmic FUS inclusion/aggregation is uncommon and observed only in FUS-related fALS (Vance et al., 2009) and a very small subset of sALS (Deng et al., 2010).