Studies using in vitro systems found that R-methylation on ALS-related RBPs, such as hnRNPA2 and FUS, reduces LLPS via inhibiting R-aromatic interaction (Hofweber et al., 2018; Qamar et al., 2018; Ryan et al., 2018). The gene discussed is HNRNPA2B1; the disease is amyotrophic lateral sclerosis.