Genetic analysis identified several ALS-related mutations in both hnRNPA1 and hnRNPA2/B1 (Kim et al., 2013; Couthouis et al., 2014; Liu et al., 2016; Naruse et al., 2018); however, the incidence is low (<1%; Taylor et al., 2016). Here, HNRNPA1 is linked to amyotrophic lateral sclerosis.