MATR3 and amyotrophic lateral sclerosis: Contrary to other ALS-related RBPs, wild-type or mutant MATR3 is primarily localized to the nucleus even under stress or in ALS postmortem tissues (Johnson et al., 2014; Gallego-Iradi et al., 2015), and the accumulation of MATR3 in the nucleus as opposed to its location in the cytoplasm mediates neurotoxicity (Malik et al., 2018).