In the miRNA-mRNA regulatory network, miR-10a-3p had 15 target genes: HMGA2, NFIA, CUX2, SLC14A1, LRRC7, APBB2, SMOC2, FAM169A, ARHGAP5, COBLL1, MAB21L2, ZBTB20, REPS2, XRN1 and PIK3CA, also acted as downregulated genes in FLT3 mutation AML of TCGA. The gene discussed is XRN1; the disease is acute myeloid leukemia.