NOTCH1 and neoplasm: SKOV3 is one of the most typical EOC cell lines, and studies revealed that MDM2 could promote epithelial and mesenchymal transition using SKOV3 4,23, and our previous studies also have found that SKOV3 could affect the differentiation and function of dendritic precursor cells via Notch1 pathway, promoting immune escape and tumor progression 5.