The expression of circ-APBB1IP in ccRCC cell lines 786-O and Caki-1 was significantly higher than that in normal renal cell line HK-2 (Fig. 2A and 2B), and a similar pattern was seen in 11 pairs ccRCC tumor tissues and tumor-distant tissues (Fig. 2C). This evidence concerns the gene APBB1IP and nonpapillary renal cell carcinoma.