In our previous study we had sequenced the entire coding region of HOXB13 in 1,250 familial non-BRCA1/2 breast cancer patients and 800 controls and identified two other, less frequent, HOXB13 missense mutations: p.P190L (i.e. NM_006361.6: c.569 C > T; NP_006352.2:p.(P190L)) and p.R268Q (i.e. NM_006361.6:c.803 G > A; NP_006352.2:p.(R268Q); rs748782183:C > T)22. The gene discussed is HOXB13; the disease is breast cancer.