The results of the current study concur with these observations in that HOXB13 p.G84E does not appear to act as a breast cancer susceptibility allele, neither in overall analyses (OR = 1.035, 95% CI = 0.859–1.246, P = 0.718) nor in analyses enriching for particular (high-risk) subgroups. This evidence concerns the gene HOXB13 and breast cancer.