HOXB13 and Familial prostate cancer: In this respect, the rare HOXB13 p.G84E germline mutation (i.e. NM_006361.6:c.251 G > A; NP_006352.2:p.(G84E); rs138213197:C > T) was found to be associated with an increased risk to develop prostate cancer by linkage analysis and candidate gene sequencing of 200 genes at the 17q21-22 linkage region5.