BRCA1 and breast carcinoma: We found that neither p.G84E nor p.R217C were associated with an increased breast cancer risk (OR = 0.81, 95% CI = 0.41–1.59, P = 0.54 and OR = 3.57, 95% CI = 0.76–33.57, P = 0.14, respectively) in 3,270 familial non-BRCA1/2 breast cancer patients and 2,327 controls22.