We identified two recurrent HOXB13 mutations in the female Dutch population, the known prostate cancer risk allele p.G84E, but also p.R217C (i.e. NM_006361.6:c.649 C > T; NP_006352.2:p.(R217C); rs139475791:G > A). Here, HOXB13 is linked to Familial prostate cancer.