Previously, Alanee et al. had found evidence that HOXB13 p.G84E conferred an increased breast cancer risk in 877 familial non-BRCA1/2 mutation carriers and 1650 controls (OR = 5.7, 95% CI = 1.0–40.7, P = 0.02)19. This evidence concerns the gene HOXB13 and breast carcinoma.