The six genes are STAT3, E2F1, HMGA2, SOX4, TWIST1, and EGFR that have been studied to be associated with EMT of CRC.5,29–38 Although it has not been studied that the genes are regulated by miR-17-5p in CRC, miR-17-5p might regulate EMT by targeting these EMT-related genes. This evidence concerns the gene STAT3 and colorectal carcinoma.