Modelling the AD-related reduced CYFIP2 expression in heterozygous Cyfip2 null mutant mice (Cyfip2+/−), which have no overt phenotypes19, led to increased APP protein expression, enhanced tau phosphorylation at CaMKII phospho-sites in synapses, elevated soluble Aβ1-42 levels, and changes in synapse morphology in the young adult hippocampus23. The gene discussed is MAPT; the disease is Alzheimer disease.