While Lrp1 deletion mediated by other Cre drivers also generated cardiac defects, unlike Wnt-1+/Cre:Lrp1f/f in which 100% of the mutant embryos exhibited CHD, fewer cardiac defects were seen in Nkx2–5+/Cre:Lrp1f/f, Mef2c-AHF+/Cre:Lrp1f/f and Tie2+/Cre:Lrp1f/f deletion embryos (12%, 14%, and 57% had normal cardiac anatomy, respectively). Here, LRP1 is linked to coronary artery disorder.