NKX2-5 and familial atrioventricular septal defect: There was a tenfold increase in the incidence of DORV with AVSD—46% with Tie2+/Cre/Nkx2–5+/Cre:Lrp1f/f double Cre deletion vs. 4% with Tie2+/Cre:Lrp1f/f.