Because of its deneddylation activity, UCHL3 appears to be unique in the UCH family.16 Some research has suggested that UCHL3 plays a role in tumorigenesis and that UCHL3 expression is upregulated in breast cancer and cervical cancer tissues.17,18 However, the specific mechanism and role of UCHL3 in tumorigenesis have not been clarified. Here, UCHL3 is linked to breast cancer.