To further investigate whether knockdown of KLF5 increased the invasiveness of PCa cells by activating STAT3, we suppressed STAT3 activation with 0.5 μM STAT3 inhibitor niclosamide, and found that blocking STAT3 activation inhibited PCa cell invasion enhanced by KLF5 knockdown (Fig. 5f). This evidence concerns the gene STAT3 and posterior cortical atrophy.