KLF5 and posterior cortical atrophy: We detected lower KLF5 mRNA expression in metastatic tumor tissues than in localized tumor tissues of PCa as evidenced by the analysis from GSE36988 (Fig. 2a), GSE6919 (Fig. 2b), and EXP00230 (Fig. 3c), indicating that KLF5 was downregulated in metastatic loci of PCa.