In the present study, we found that knockdown of IGF1 and its blockage with antibody significantly suppressed the activation of STAT3 in PCa cells (Figs. 3 and 4), which is consistent with a previous study that IGF1/IGF1R could activate STAT3 and its downstream target genes such as MMP922. The gene discussed is IGF1; the disease is posterior cortical atrophy.