To determine whether the low DINO levels in HPV-positive cervical cancer lines were a consequence of HPV E6/UBE3A-mediated TP53 destabilization, HPV16 E6, alone or in combination with TP53, was depleted in HPV16-positive SiHa cells by transient transfection of the corresponding small interfering RNAs (siRNAs). This evidence concerns the gene UBE3A and cervical carcinoma.