CDKN1A and cervical carcinoma: Given that HPV16 E6 depletion increased DINO levels and caused a TP53-dependent increase in the TP53 transcriptional target CDKN1A in the HPV-positive SiHa cervical cancer line (Fig. 1), we next determined whether the dormant TP53 tumor suppressor pathway may be restored by DINO expression.