In the case of LMP1, different cargos have been found to be packaged into EVs, including EGF receptor (EGFR), fibroblast growth factor 2 (FGF-2), PI3K, and HIF1α, which play major roles in angiogenesis, tumor growth, and metastasis (9, 11, 70). This evidence concerns the gene HIF1A and neoplasm.