Given the evidence for association of multiple FA genes with EOC risk, we also carried out a burden test to compare the frequency of deleterious variants in any of the eight genes which were not significantly associated with ovarian cancer risks individually (FANCA, FANCB, FANCC, FANCD2, FANCE, FANCG, FANCI and FANCL). The gene discussed is FANCA; the disease is ovarian cancer.