As reported, salidroside can regulate Rho/ROCK1/NF-κB pathway to ameliorate arthritis-induced brain cognition deficits and microRNA-145 can inhibit proliferation and promote apoptosis of hepatocellular carcinoma through downregulation of ROCK1/NF-κB pathway [42, 43]. The gene discussed is NFKB1; the disease is arthritic joint disease.