To sum up, DIM could modulate AHR to transfer into the nuclei for participation in transcription activity and to weaken interaction with EGFR leading to inhibition of RhoA/ROCK1-mediated COX2/PGE2 pathway connected by NF-κB to finally reverse EMT process of ESCC (Fig. 8e). The gene discussed is ROCK1; the disease is esophageal squamous cell carcinoma.