In this study, the serum concentrations of BME cytokines (CaN, OPG, PTHrP, and IL-6) and bone turnover markers (tP1NP and β-CTx) were analysed in 205 lung cancer patients, and these bone biochemical markers were comprehensively analysed in relation to bone metastasis in lung cancer. Here, TNFRSF11B is linked to lung cancer.