Given that inhibition of IGF-1R restrained YAP expression and showed anti-tumor effects on DLBCL cells, our findings indicate that targeting IGF-1R activity may produce therapeutic value in DLBCL by restricting YAP activity, which raises the possibility that molecular therapies targeting YAP will provide an attractive precise treatment strategy for DLBCL. This evidence concerns the gene IGF1R and neoplasm.