IGF1R and diffuse large B-cell lymphoma: DLBCL cell lines were treated with two structurally unrelated IGF-1R inhibitors, AG1024, a member of the tyrphostins molecule class that specifically inhibit the autophosphorylation of the tyrosin residue on IGF-1R [33], and PPP, a cyclolignan alkaloid that specifically inhibits the activity and downregulates the cellular expression of IGF1R without interfering with the activities of other growth factor receptors [34].