However, neither commercially available human IgG nor IgG from children with JIA or anti-NMDAR encephalitis had a significant impact on the concentration of CD11b (Fig. 1c, d), suggesting that upregulation of CD11b induced by serum IgG from children with OMS and NB is not simply induced by increased dose of IgG, is not common to all diseases with IgG, and is not common to all autoantibody-mediated disorders of the CNS. This evidence concerns the gene ITGAM and central nervous system disorder.