Taken together, IgG from children with OMS and NB increases the activation of microglias, leading to the upregulation of NO, which subsequently activates sGC and PKG in neurons to induce neuronal lysis, at the same time IGF-1/PI3K signaling may be compensatively activated to alleviate neuronal lysis; however, the role of NO and its intracellular cascade seems to be more predominant (Fig. 11). The gene discussed is IGF1; the disease is neuroblastoma.