To further investigate the effects of serum IgG from children with OMS and NB on microglial activation, the concentrations of proinflammatory cytokines (including IL-1β, IL-6, TNF-α, and MCP-1) and NO in the media of cerebral cortical and cerebellar microglias were detected by ELISA. The gene discussed is IL6; the disease is opsoclonus-myoclonus syndrome.