The action of angiotensin II results in increased glomerular capillary pressure in hypertension with renal damage, resulting in increased glomerular permeability and excessive proteins being filtered through the glomeruli; cells in the proximal convoluted tubule absorb the excessive proteins by pinocytosis, which causes tubular damage, interstitial inflammation and fibrosis, as well as the loss of kidney unit function [24]. This evidence concerns the gene AGT and hypertensive disorder.