KEAP1 and Parkinson disease: NRF2 deficiency has been found in several NDDs; for instance, the hippocampal neurons of AD patients showed a dramatic decrease in nuclear NRF2 [59], while animal models of PD, such as NRF2-knockout mice, showed a specific loss of dopaminergic neurons [60] and post-mortem studies of patients with ALS showed an increased KEAP1 mRNA in the motor cortex [61], leading to a decline in NRF2 activity.