FLT3 and acute myeloid leukemia: To uncover genes whose knockout produces a phenotypic effect that synergize with the effect of inhibition of FLT3 in promoting cell death we conducted genome-wide Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 loss-of-function screens in a human AML cell line with application of selective pressure from midostaurin.