INS and Insulin resistance: In addition, the inflammation condition present in obese patients, with increased concentrations of proinflammatory cytokines and high presence of macrophages in adipose tissue can have a significant impact on the functioning capacity of insulin, not only by reducing the secretory function of the β cells pancreatic up to apoptosis, but also by attenuating the insulin receptor’s ability to propagate downstream transduction [10,92] and promote the condition of insulin resistance [93].