Thus, here we aim to: (i) gain molecular insight for the role of the YWHAZ truncating mutation p.L220Ffs*18 previously reported in a family with distinct psychiatric disorders; (ii) assess the contribution of common and rare variants of the 14-3-3 gene family (SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ) to ASD and other psychiatric disorders; and (iii) explore possible altered expression levels of this gene family in psychiatric disorders. This evidence concerns the gene YWHAE and psychiatric disorder.