Interestingly, several members of the 14-3-3 gene family have been implicated in psychiatric disorders, including reported associations of YWHAB, YWHAE, YWHAZ and YWHAH with schizophrenia [34,35,36,37,38,39]; YWHAE and YWHAQ with ADHD [39]; YWHAH, YWHAG and YWHAE with bipolar disorder [39,40]; YWHAE and YWHAQ with major depressive disorder [39,41]; and YWHAE with suicide attempts [42]. This evidence concerns the gene YWHAH and major depressive disorder.