Interestingly, microduplications of YWHAE, which encodes 14-3-3ε that form stable heterodimers with 14-3-3ζ, were reported in ASD patients; whereas microdeletions involving both YWHAE and PAFAH1B1 genes cause Miller–Dieker syndrome, a form of lissencephaly with ID and seizures [49,50,51,52,53], and deletions including YWHAG and HIP1 were related to epilepsy, learning problems and ID [54]. Here, YWHAE is linked to lissencephaly spectrum disorders.