Animal models deficient for 14-3-3 proteins show a variety of behavioural manifestations related to psychiatric disorders: Ywhaz (14-3-3ζ) deficient mice present hyperactivity, impaired memory, lower anxiety and impaired sensorimotor gating [32,33]; Ywhae (14-3-3ε) deficient mice present enhanced anxiety-like behaviour, defects in working memory, increased locomotor activity and sociability [34,55]; and heterozygous knock-out mice deficient for Ywhag (14-3-3γ) show hyperactivity and depressive-like behaviour [56]. This evidence concerns the gene YWHAE and Anxiety.