CNP and Peripheral demyelination: FTY720 treatment also promoted OPC differentiation in cultured human and rodent oligodendrocytes [43,110,114,116,119] and in the CNS of a number of rodent demyelination models [48,56,64,66,107,110,111,117], as shown by the increased mRNA and protein expression of the mature myelin markers myelin basic protein (MBP), proteolipid protein (PLP1) and 2′,3′-cyclic-nucleotide 3′-phosphodiesterase (CNPase).