Moreover, the density of cells positive for the pro-inflammatory microglia markers integrin alpha-M precursor (MAC-1/ITGAM) and galectin-3 (MAC-2) was decreased in PLP- and MOG-induced EAE mice [164,165,166] and in a double-transgenic (APP/Presenilin-1; PS1) mouse AD model [167]. The gene discussed is ITGAM; the disease is Alzheimer disease.