In addition, FTY720 inhibited the degree of phosphorylation of NFκB and p65 both after cellular stress by OGD and in unstimulated primary astrocyte cultures [65,90,92,93], and increased the inhibitor NFκB-alpha (Iκbα) levels in a mouse HD model [84], both leading to a reduced NFκB activation. Here, NFKB1 is linked to Huntington disease.