TLR4 and inflammatory response: Similarly, genetic sequences of immune cells’ superficial and intracellular receptors have been incriminated for intense gastric inflammation, dysplasia and oncogenesis; rs11535889 polymorphism of Toll-like receptor-4 and rs718226 polymorphism of nucleotide-binding oligomerisation domain-like receptors (NOD)-2 have been found in different Chinese sub-populations thus predisposing to gastric cancer, whereas the E266K single nucleotide polymorphism of NOD1 was connected with intense inflammation in Korean patients [81].