To do this, we first analyzed the association of NF-κB activation levels with renal parameters in the black and tan, brachyuric (BTBR) obese/obese (ob/ob) mouse—an obesity-associated T2D (diabesity) model that offers great translational opportunities due to its similar hallmarks of human DN [33,34]. Here, NFKB1 is linked to obesity due to melanocortin 4 receptor deficiency.