In T2D, chronic hyperglycemia, salt-sensitive hypertension and obesity produce metabolic, hemodynamic and lipotoxic effects described as main activators of intracellular signaling pathways such as nuclear factor kappa–B (NF-κB), Janus Kinase/Signal Transducers and Activators of Transcription (JAK/STAT) and nuclear factor erythroid 2-related factor 2/heme-oxigenase-1(Nrf2/Hmox-1) [9,10,11,12]. The gene discussed is NFE2L2; the disease is obesity due to melanocortin 4 receptor deficiency.