CD4 and myeloid sarcoma: Whereas, Vanheusden et al. demonstrated expansion of CD4+CD28null T cells in MCMV infection in mice with these cells associated with aggravation of the inflammation, demyelination and worsening symptoms of experimental autoimmune encephalomyletis (EAE), a mouse model of MS induced by the injection of myelin antigens with adjuvant EAE [63].