Mechanistically, ZEB1 is a transcriptional repressor of epithelial differentiation genes, such as cdh1 encoding the E-cadherin adherent junction protein and other cell polarity complex genes, promoting the trans-differentiation characterized by a more or less important loss of epithelial integrity and the acquisition of a highly motile mesenchymal phenotype and invasion properties in cancer [61]. This evidence concerns the gene CDH1 and cancer.