Mice lacking Nlrp3, Asc and caspase-1 gene expression are more vulnerable to experimental colitis induced by 2,4,6-trinitrobenzenesulfonic acid (TNBS) and dextran sodium sulfate (DSS), both characterized by diarrhea, body weight loss, rectal bleeding and mortality, proposing the favorable action of NLRP3 complex in the colon tissue. This evidence concerns the gene CASP1 and colitis.