INS and Insulin resistance: Accordingly, HFD offspring showed increased insulin resistance as reflected by increased HOMA-IR (males: F1c: 15.9 ± 2.0 vs. F1m: 48.6 ± 10.4, p = 0.002; females: F1c: 5.9 ± 0.8 vs. F1m: 10.5 ± 1.4, p = 0.002), and higher basal insulin levels as compared to offspring of the control group (males: F1c: 3.2 ± 0.4 ng/mL vs. F1m: 8.6 ± 1.7 ng/mL, p = 0.003; females: F1c: 1.3 ± 0.2 ng/mL vs. F1m: 2.2 ± 0.2, p = 0.004); both alterations were more pronounced in males (Figure 2B,C).