At weaning on day 21 of life, offspring of both groups and sexes did not differ in body weight, but male F2m offspring showed obesity, characterized by increased body fat content (+11%; F2c: 8.7 ± 0.3% vs. F2m: 9.6 ± 0.3%, p = 0.034) and elevated plasma leptin levels (+27%; F2c: 2.6 ± 0.2 ng/mL vs. F2m: 3.3 ± 0.2 ng/mL, p = 0.043) as compared to controls. Here, LEP is linked to obesity due to melanocortin 4 receptor deficiency.