Among the aberrantly activated pathways in MCL, canonical Wnt signaling has been associated with the expression of the zinc finger E-box binding homeobox 1 (ZEB1) transcription factor, responsible for the activation of proliferation-associated genes such as CCND1, MYC, and MKI67 and anti-apoptotic genes, including MCL1 and BCL2 [106,107]. The gene discussed is CCND1; the disease is mantle cell lymphoma.