In our in vitro proliferation assays, Fhit-transfected tumor cells showed a very strong susceptibility to TNF-α and a partial susceptibility to IFN-γ, while TGF-β increased the proliferative rate of the non-transfected tumor cells but had no effect on this rate in the Fhit-transfected tumor cells (Figure S6B). This evidence concerns the gene TGFB1 and neoplasm.