FHIT and neoplasm: Further research is warranted to explore the possibility that FHIT expression recovery by in vivo FHIT-transfection or other means, or the use of in vitro irradiated Fhit-transfected tumor cells might be useful as a personalized immunotherapeutic antitumor vaccine in human patients with FHIT-negative and MHC-I-downregulated tumors.