Because IFN-γ treatment of tumor cells has similar effects at transcriptional level, inducing MHC-I expression in vitro, we hypothesized that the induction of MHC-I expression by Fhit might be mediated by the following signal pathway: Fhit → IFN-γ-pathway genes → APM/MHC genes → MHC-I cell surface expression. This evidence concerns the gene ANPEP and neoplasm.