The NPM1 locus is involved in translocations causing hematologic malignancies such as acute promyelocytic leukemia where t(5;17)(q35;q12) leads to NPM1–RARα, anaplastic large cell lymphoma where t(2;5)(p23;q35) leads to NPM1-ALK, and myeloid neoplasms where t(3;5)(q25;q35) leads to NPM1-MLF1 [47,48,49]. Here, NPM1 is linked to anaplastic large cell lymphoma.