The study also investigated pathological changes related specifically to the liver, demonstrating that sEH inhibition by t-AUCB attenuated HCHF diet-induced liver hypertrophy, steatosis, and injury (confirmed by decreased lactate dehydrogenase and aspartate aminotransferase levels [LDH and AST, respectively], plasma biomarkers of liver injury). Here, EPHX2 is linked to steatosis.