The ER stress associated with NAFLD/metabolic syndrome was also attenuated by sEH inhibition in this study, as demonstrated by decreased protein levels of phosphorylated IRE1α and eIF2α (which lies downstream of PERK), thereby corroborating the protection against ER stress previously shown by Bettabieb et al. with a different sEHI. This evidence concerns the gene EPHX2 and metabolic dysfunction-associated steatotic liver disease.