RYR2 and Ventricular arrhythmia: In this regard, it may be noted that genetic alterations in RyR2 are associated with catecholaminergic polymorphic ventricular tachycardia, a type of adrenergic-induced ventricular arrhythmias triggered by exercise and emotional stress, which may cause syncope and sudden cardiac death in the absence of any structural defect in the heart [82,83,84].