In particular, tumor cells release chemokines (such as, SDF-1, MIP-1, MCP-1, MIP-2, etc.)that trigger the activation of SRC kinase in immune cells, which in turn release other cytokines (TNF-α, IL-1β, IL-6, etc.)reciprocally activating SRC in cancer cells through a positive feedback mechanism. Here, IL1B is linked to neoplasm.