Both PBC and PSC patients with cirrhosis had lower number of CTLA4 copies [mean: 4359 copies (CI:2655–6278)] than patients without cirrhosis [mean: 6836 copies(CI:5991–7746)] with a p-value of 0.04 in the t-test as depicted in Figure 1 Panel A. Number of ICOS-copies showed a similar result: cirrhosis [mean: 50 984(CI:25978–80493)] vs. no cirrhosis [mean: 79248(CI:68837–90431)] with a p-value of 0.05. The gene discussed is CTLA4; the disease is Cirrhosis.