LRP1 and cancer: Indeed, if low LRP-1 expression has been associated with advanced tumor stages and poor survival in several cancers (hepatocellular carcinoma [48], lung adenocarcinoma [49], melanoma [50], and Wilms tumors [51]), high LRP-1 expression has been related to advanced tumor stages (in endometrial carcinoma [52], breast cancer [53], prostate carcinomas [54], and colon cancer [55]).