To determine the role of ω-3 PUFA-derived metabolites in NV, Sapieha et al. [125] fed ω-3 PUFA diets into COX-1 KO, COX-2 KO, 5-LOX KO, 12/15-LOX KO, and WT mice, and then retinopathy was induced by oxygen exposure (OIR). The gene discussed is LOX; the disease is retinal disorder.