The search for key players is generally on: (a) mutated genes that are more frequently found in patients with glaucoma (single nucleotide polymorphisms [SNP] databases; e.g., CAV-1), (b) genes affected by glaucoma (e.g., data from [single-cell] RNAseq healthy-disease condition databases; e.g., ANGPTL7, MMP1, and PLAT), or (c) gene products that are actively involved in regulating the intraocular pressure (e.g., data from knock-out/in gene library screens and literature searches; e.g., RhoA-Rho kinases and prostaglandin EP4 agonists) [203]. The gene discussed is RHOA; the disease is glaucoma.