Furthermore, a dual-acting rAAV2/5 vector expressed the miRNA (5, B, 7), against Vascular endothelial growth factor A (VEGFA) and antiangiogenic protein pigment endothelial-derived factor (PEDF) driven by an RPE-specific Bestrophin 1 (VMD2) promoter, suppressed choroidal neovascularization in a wet-AMD mouse model [87]. This evidence concerns the gene BEST1 and wet macular degeneration.