The mutant rhodopsin gene encoding a dominant-negative form of rhodopsin (RhoP23H/P23H) was also silenced by gene editing in a mouse model of retinal degeneration (RhoP23H/P23H) by a dual rAAV-vector administration (rAAV2/8(Y733F)-sCMV-SpCas9.spA and rAAV2/8(Y733F)-U6.gRNA1gRNA2(mRho).mRho.hRHO.SV40-polyA) rescuing retinal degeneration [61]. This evidence concerns the gene RHO and retinal degeneration.