Following an additional 12 weeks of the HF/S diet, CIDEC, PPARγ FOXO1, HADH, FABP4, SIRT1, and TRPV4 expression was significantly lower in the CON group compared to the OBC group in male mice (p < 0.01, Figure 3A,E,G,I,K,M,O). The gene discussed is SIRT1; the disease is hydrops fetalis.