EDNRA and aortic aneurysm: ET-1 through its ETA-R, which is also expressed in endothelial cells, smooth muscle cells, and cardiomyocytes, would lead to the damage of the cardiac tissue and an aortic aneurysm by the activation of various proinflammatory pathways, mainly that of NADPH oxidase, but also the activation and the recruitment of inflammatory cells including macrophages and polymorphonuclear neutrophils (PMN) with the release of proinflammatory mediators and MMP overexpression, thereby resulting in an overall cardiovascular dysfunction.