The most frequent PPO was in 31.1% of patients, who were prescribed regular opioids without a laxative, 6.9% had osteoporosis but were not prescribed bone anti-resorptives, 5.7% had heart failure or coronary artery disease but were not prescribed angiotensin converting enzyme inhibitors (ACE) (Figure 3, Table S4). The gene discussed is ACE; the disease is coronary artery disorder.