Other RBPs with suggested tumor-promoting roles in PDAC include the 5’-3’ exonuclease EXO1 [21] and the RBPs HuR (ELAVL1) and PTBP3, which both have been reported to lead to hypoxia-induced chemoresistance in pancreatic cancer cells [22,23]. This evidence concerns the gene ELAVL1 and familial pancreatic carcinoma.