TWIST1 and neoplasm: EMT is driven by a set of transcriptional factors, including Snail (also known as SNAI1), Slug (also known as SNAI2), Twist-related protein 1 (TWIST1), zinc-finger E-box-binding homeobox 1 (ZEB1) and ZEB2, that regulate gene expression alterations which culminate with enhanced tumor cell migration, invasion, and metastatic properties [7,8].