Previous published studies demonstrated that IL-8 was a significant discriminator of NASH severity because of its associations with advance of steatosis degree [57], with steatosis degree and lobular inflammation [14,66], fibrosis [39], hepatocyte ballooning and significant fibrosis [25], and cirrhosis [67]. The gene discussed is CXCL8; the disease is metabolic dysfunction-associated steatohepatitis.