OPA1 and Sepsis: As shown in Figure 6A, sepsis in GFP expressing muscles resulted in a decrease in the mRNA levels of pro-fusion Mfn2 and Opa1 and pro-fission Drp1. In Parkin overexpressing muscles, CLP resulted in a significant decrease in the mRNA levels of Mfn2 and Drp1, while Opa1 expression remained unaffected, shown in Figure 6A. At the protein level, no impact of sepsis or Parkin overexpression could be evidenced on MFN2 and OPA1 protein content.