We found that tumor take was similar for APLN-knockdown (87% for U87AKDAPLNWT) compared to U87NSC control cells (90% for U87NSCAPLNWT) when implanted in WT mice and only slightly reduced when APLN was missing in the tumor microenvironment in APLNKO but still present in the tumor cells (72% for U87NSCAPLNKO xenografts). This evidence concerns the gene APLN and neoplasm.