Therefore, we infused the bioactive apelin-13 peptide into the U87AKDAPLNKO xenograft model and were indeed able to obtain a partial rescue of the tumor neo-vasculature increasing VLD from 766 mm/mm3 (infusion of artificial cerebrospinal fluid; aCSF control) to 2573 mm/mm3 (Figure 4). Here, APLN is linked to neoplasm.