APLN and glioma: Using APLN expression levels in mouse wildtype (WT) brains as a comparison, we characterized the human cell-line U87MG as having high levels of APLN expression and the human U251 (formerly known as U373MG) cell line expression as being lower, whilst in the murine GL261 glioma cell-line APLN expression was not detectable (n.d.; Figure 1A).