Although the reporters without HIFα transactivation domains are not capable of enhancing this machinery, the described dynamics apparently are common to all ODD-based reporters due to natural HIF-1α accumulation, given that after reoxygenation, the ODD-GFP half-life in C6 glioma cells declined from 6 h [87] to 3 min [88]. This evidence concerns the gene HIF1A and central nervous system cancer.